Down-regulation of BORIS/CTCFL efficiently regulates cancer stemness and metastasis in MYCN amplified neuroblastoma cell line by modulating Wnt/β-catenin signaling pathway

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• 作者：Koteswara Rao Garikapati^a ; ^c ; Nibedita Patel^a ; Venkata Krishna Kanth Makani^a ; Priyanka Cilamkoti^a ; Utpal Bhadra^b ; Manika Pal Bhadra^a ; ^{manikapb@gmail.com}
• 关键词：BORIS/CTCFL ; Cancer stemness ; Wnt/β-catenin signaling ; Metastasis and EMT/MET
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：93-99
• 全文大小：2383 K
• 卷排序：484

文摘

BORIS/CTCFL is re-expressed in many cancer conditions. BORIS/CTCFL is responsible for Cancer Stemness and Cancer Stem cell Population. Knockdown of BORIS/CTCFL effectively controlled Cancer Stemness. Knockdown of BORIS/CTCFL effectively reversed the EMT/MET switch.