The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish

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• 作者：Yang Wu^a ; Guanyong Su^a ; Song Tang^b ; Wei Liu^a ; ^c ; Zhiyuan Ma^a ; Xinmei Zheng^a ; Hongling Liu^a ; ^{hlliu@nju.edu.cn} ; Hongxia Yu^a ; ^{yuhx@nju.edu.cn}
• 关键词：Flame retardant ; Nuclear receptors ; Endocrine disrupting ; In silico ; Signaling pathways ; Panoramic map
• 刊名：Chemosphere
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：122-130
• 全文大小：1718 K
• 卷排序：168

文摘

The endocrine disrupting effects of TCEP on zebrafish were thoroughly evaluated. Both in silico and in vivo approaches were conducted. A panoramic map of signaling pathways was generated. ERs, ThR, RXRs and RyRs are key receptors influenced by TCEP.