Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway
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- 作者：Cheng Chena ; 1 ; Kaipeng Huangb ; 1 ; Jie Haoc ; 1 ; Junying Huanga ; Zhiying Yanga ; Fengxiao Xionga ; Peiqing Liua ; Heqing Huanga ; huangheq@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetic nephropathy ; Advanced glycation-end products ; Polydatin ; Sphingosine kinase 1 ; Fibronectin ; Intercellular adhesion molecule-1
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：45-56
- 全文大小：2701 K
文摘
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PD evidently suppressed the expression of FN and ICAM-1 in AGEs-induced GMCs and diabetic db/db mice kidneys.
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PD evidently suppressed protein expression and activity of SphK1 in AGEs-induced GMCs and diabetic db/db mice kidneys.
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PD evidently suppressed the DNA-binding activity and transcriptional activity of AP-1 in AGEs-treated GMCs.
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Inhibition of the SphK1-S1P signaling may be a new mechanism underlying the anti-DN effects of PD.