Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts
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- 作者：Katsumasa Higashia ; Etsuko Matsuzakia ; b ; matsuzaki@college.fdcnet.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoko Hashimotoa ; Fumi Takahashi-Yanagac ; Aiko Takanoa ; Hisashi Ananb ; Masato Hiratad ; hirata1@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Fusanori Nishimuraa
- 关键词：ALP ; alkaline phosphatase ; BMP ; bone morphogenetic protein ; ERK ; extracellular signal regulated protein kinase ; GSK-3β ; glycogen synthase kinase 3β ; I-Smad ; inhibitory Smad ; PI3K ; phosphatidylinositol 3-kinase ; ROCK ; Rho kinase ; ROI ; region of interest ; Runx2 ; Runt-related transcription factor 2 ; S1P ; sphingosine-1-phosphate
- 刊名：Bone
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：1-11
- 全文大小：1722 K
文摘
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Sphingosine 1-phosphate (S1P) activates S1PR2 as well S1PR1 in osteoblasts.
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Activation of S1P/S1PR2 promotes the signaling such as RhoA and the kinase (ROCK).
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Activation of S1P/S1PR2/RhoA/ROCK signaling induces phosphorylation of Smad1/5/8.
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The phosphorylation induces the expression of Runx2 and alkaline phosphatase.
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S1P/S1PR2 signaling is important for osteogenesis in vivo as well as in vitro.