刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:January 2017
年:2017
卷:1863
期:1
页码:253-265
全文大小:2826 K
卷排序:1863
文摘
HH signaling and SOX2 function are inclined to developmental cues and arbitrating malignant growth. SOX2 inhibition reduces cell proliferation and induces apoptosis. Conjoint inhibition of SOX2 and HH pathway induce apoptosis, reduce proliferation and migration. This inhibition decrease in E-cadherin and Bcl-2 and increase Bax expression. HH-SOX2 axis is a better therapeutic target than individual treatment policies.