Spatiotemporal dynamics of the calcineurin target CrzA

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• 作者：Patricia Herná ; ndez-Ortiz¹ ; Eduardo A. Espeso ; ^{eespeso@cib.csic.es}
• 关键词：Filamentous fungi ; Calcineurin ; Calcium signaling ; Nucleo-cytoplasmic trafficking ; Transcription factor
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：168-180
• 全文大小：1706 K
• 卷排序：29

文摘

Signaling of CrzA occurs in a basipetal, tip to nucleus, manner and dependent on the apical localization of calmodulin and calcineurin together with actin cytoskeleton. CrzA is the only element of its signaling pathway that changes in localization after calcium or alkaline pH stress. Calcineurin is the key factor in the spatiotemporal dynamics of CrzA in the fungal cell. Timing of nuclear localization of CrzA depends on the strength and nature of ambient stimulus.