A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase
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- 作者：Emil Peter Thrane Hertz1 ; 3 ; Thomas Kruse1 ; 3 ; thomas.kruse@cpr.ku.dk" class="auth_mail" title="E-mail the corresponding author ; Norman E. Davey2 ; Blanca Ló ; pez-Mé ; ndez1 ; Jó ; n Otti Sigurð ; sson1 ; Guillermo Montoya1 ; Jesper V. Olsen1 ; Jakob Nilsson1 ; jakob.nilsson@cpr.ku.dk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：18 August 2016
- 年：2016
- 卷：63
- 期：4
- 页码：686-695
- 全文大小：4581 K
文摘
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The PP2A-B56 holoenzyme binds to short linear LxxIxE motifs in eukaryotes
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LxxIxE motifs are recognized by a conserved binding pocket on B56 regulatory subunits
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LxxIxE motifs can provide PP2A-B56 substrate specificity