micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine

详细信息    查看全文

• 作者：Hao Hu^a ; ¹ ; ^{haohu@ntu.edu.cn} ; Yuan He^b ; ¹ ; Yandong Wang^c ; Wuqiang Chen^a ; Benshun Hu^a ; YuanLong Gu^a ; ^{guyuanlongnty@163.com}
• 关键词：micorRNA-101 ; DNA-PKcs ; Gemcitabine ; Pancreatic cancer and Akt
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：725-731
• 全文大小：533 K
• 卷排序：483

文摘

miR-101 expression downregulates DNA-PKcs and sensitizes PANC-1 cells to gemcitabine. antagomiR-101 expression causes DNA-PKcs upregulation and gemcitabine resistance. DNA-PKcs inhibition/silence disables miR-101-mediated gemcitabine-sensitization. miR-101 expression inhibits Akt activation in PANC-1 cells. miR-101 downregulation and DNA-PKcs upregulation in gemcitabine-resistant pancreatic cancer tissues.