Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5
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- 作者：Tami S. McMullina ; 1 ; tami.mcmullin@state.co.us" class="auth_mail" title="E-mail the corresponding author ; Yuching Yangb ; Jerry Campbellb ; jcampbell@thehamner.org" class="auth_mail" title="E-mail the corresponding author ; Harvey J. Clewellb ; hclewell@thehamner.org" class="auth_mail" title="E-mail the corresponding author ; Kathy Plotzkea ; kathy.plotzke@dowcorning.com" class="auth_mail" title="E-mail the corresponding author ; Melvin E. Andersenb ; mandersen@thehamner.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Octamethylcyclotetrasiloxane ; Decamethylcyclopentasiloxane ; D4 ; D5 ; Siloxane ; PBPK ; Kinetics ; Risk assessment ; Cyclic volatile methyl siloxane ; Pharmacokinetics ; Physiologically based pharmacokinetic model
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：74
- 期：supp_S
- 页码：S1-S13
- 全文大小：3661 K
文摘
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A single multi-species, multi-route PBPK model for cyclic siloxanes is presented.
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Key parts of several existing models were integrated using a nested approach.
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The model behavior has high concordance across multiple rodent and human datasets.
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This single model construct will improve risk assessments for cyclic siloxanes.