Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome
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- 作者：Marja Pertovaaraa ; b ; marja.pertovaara@uta.fi" class="auth_mail" title="E-mail the corresponding author ; Olli Silvennoinenb ; c ; Pia Isomä ; kia ; b
- 关键词：Interferon-α ; Interferon-γ ; Interleukin-6 ; Phosphorylation ; Sjö ; gren's syndrome ; STAT
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：165
- 期：Complete
- 页码：60-67
- 全文大小：1433 K
文摘
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Cytokine-stimulated STAT1 phosphorylation is upregulated in PBMCs from patients with pSS.
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STAT1-mediated gene expression is enhanced in pSS patients.
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Sensitivity of immune cells to STAT1-activating signals may contribute to the IFN signature in pSS.