Aristaless-Like Homeobox protein 1 (ALX1) variant associated with craniofacial structure and frontonasal dysplasia in Burmese cats
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- 作者：Leslie A. Lyonsa ; f ; Lyonsla@Missouri.edu" class="auth_mail" title="E-mail the corresponding author ; Carolyn A. Erdmanb ; f ; Robert A. Grahnc ; f ; Michael J. Hamiltond ; f ; Michael J. Cartere ; f ; Christopher R. Helpsg ; Hasan Alhaddadh ; Barbara Gandolfia ; f
- 关键词：Cartilage homeo protein 1 ; CART1 ; Domestic cat ; Facial development ; Frontonasal dysplasia ; FND ; Felis silvestris catus
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：409
- 期：2
- 页码：451-458
- 全文大小：1765 K
文摘
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Cat breeds are models for mammalian frontonasal development.
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A 12 bp in frame deletion in ALX1 is 100% concordant with a cat craniofacial defect.
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The ALX1 variant in cats has a heterozygous advantage in Burmese cat breeding.
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Cats with frontonasal dysplasia could facilitate early developmental therapeutics.