To compare IFN-伪 levels in dengue patients with dengue fever (DF) or dengue hemorrhagic fever (DHF) undergoing primary or secondary infections.
Two hundred and four serum samples were analyzed for IFN-伪 level by cytometric bead array. Patients’ clinical condition was assigned following the WHO 1997 criteria and specific IgG and IgM antibodies were measured using commercial assays to determine primary and secondary infections. The infecting serotype was determined by qRT-PCR.
The IFN-伪 levels were found significantly higher in DF than DHF patients irrespective of the infecting serotype (DENV1 or 2), and were found to decline rapidly at day 3 after fever onset. For DENV2 infections, higher IFN-伪 level was found during primary than secondary infections. These results suggest that an early strong interferon response correlates with a better clinical condition.