PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release Machinery
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- 作者：Pierluigi Valente1 ; Enrico Castroflorio1 ; 2 ; Pia Rossi1 ; Manuela Fadda1 ; Bruno Sterlini1 ; 2 ; Romina Ines Cervigni3 ; Cosimo Prestigio1 ; 2 ; Silvia Giovedì ; 1 ; Franco Onofri1 ; Elisa Mura3 ; Fabrizia C. Guarnieri3 ; Antonella Marte1 ; Marta Orlando2 ; Federico Zara4 ; Anna Fassio1 ; 2 ; Flavia Valtorta3 ; Pietro Baldelli1 ; 2 ; Anna Corradi1 ; 5 ; Fabio Benfenati1 ; 2 ; 5 ; fabio.benfenati@iit.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：PRRT2 ; knockdown ; synaptic transmission ; synchronous and asynchronous release ; release probability ; synaptotagmin
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：117-131
- 全文大小：5682 K
文摘
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PRRT2 is a presynaptic protein
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PRRT2 is required for synchronous neurotransmitter release
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PRRT2 silencing decreases synaptic density and release probability
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PRRT2 interacts with the fast Ca2+ sensors synaptotagmin 1/2