Melatonin delivery by nanocapsules during in vitro bovine oocyte maturation decreased the reactive oxygen species of oocytes and embryos
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- 作者：Mariana Hä ; rter Remiã ; oa ; Caroline Gomes Lucasa ; William Borges Dominguesa ; Tony Silveiraa ; Nathaniele Nebel Barthera ; Eliza Rossi Komninoua ; Andrea Cristina Bassob ; Denise Soledade Jornadac ; Ruy Carlos Ruver Beckc ; Adriana Raffin Pohlmannd ; Antonio Sé ; rgio Varela Juniore ; Fabiana Kö ; mmling Seixasa ; Vinicius Farias Camposa ; Silvia Stanisç ; uaski Guterresc ; Tiago Collaresa ; tiago.collares@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antioxidant ; Bovine oocyte ; In vitro maturation ; Melatonin ; Lipid-core ; Nanocapsules ; Nanotechnology
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：70-81
- 全文大小：3074 K
文摘
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Supplementation of Mel-LNC during in vitro Maturation increases cleavage and blastocyst rates.
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Decrease of ROS levels and apoptotic cell number/blastocyst are found at Mel-LNC group.
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Mel-LNC upregulates GPX1 and SOD2 and downregulates CASP3 and BAX genes.
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Mel-LNC is able to cross zona pellucida in oocytes Maturation.