Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages
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- 作者：Simona Stavria ; Maya Simionescua ; Dimitris Kardassisb ; Anca V. Gafencua ; anca.gafencu@icbp.ro" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apolipoprotein E ; CREB ; KLF4 ; Gene regulation ; Monocyte differentiation ; Macrophage
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：66-72
- 全文大小：849 K
文摘
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KLF4 and apoE are synchronously induced during monocyte/macrophage differentiation.
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KLF4 up-regulates apoE gene in a dose-dependent manner.
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Biologically active KLF4 binding sites are present on apoE promoter.
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CREB enhances KLF4 up-regulatory effect on apoE promoter.