The experience of a regional pediatric intestinal failure program: Successful outcomes from intestinal rehabilitation

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• 作者：Patrick J. Javid ; Frances R. Malone ; Jorge Reyes ; Patrick J. Healey ; Simon P. Horslen
• 关键词：Intestinal failure ; Short bowel syndrome ; Intestinal rehabilitation ; Intestinal transplantation ; Pediatrics
• 刊名：The American Journal of Surgery
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：199
• 期：5
• 页码：676-679
• 全文大小：134 K

文摘

Background

The aim of this study was to evaluate the clinical experience of a regional multidisciplinary intestinal failure program for children established in 2005.

Methods

Data were collected from a prospective internal database. Univariate analyses were performed to compare pre- and post-treatment outcomes. Median values are reported.

Results

Forty-nine children were referred at an age of 7 months. Remnant small bowel length was 29 cm. With follow-up of 14 months, overall patient survival was 88 % . Thirteen bowel-lengthening procedures were performed, thereby increasing small bowel length from 83 to 132 cm (P < .05). Enteral autonomy was achieved in 22 patients (45 % ), and the caloric requirement for parenteral nutrition was decreased from 100 % to 41 % (P < .01). Conjugated bilirubin was reduced from 4.1 to 0 mg/dL (P < .05).

Conclusion

A multidisciplinary approach to pediatric intestinal failure that prioritizes intestinal rehabilitation can achieve successful enteral feeding advancement, improved liver function, and excellent survival in intermediate-range follow-up.