- 作者：Andrea G. Varon ; Simone A. Nouer ; Gloria Barreiros ; Beatriz Moritz Trope ; Fabiana Magalh茫es ; Tiyomi Akiti ; Marcia Garnica ; Marcio Nucci
- 关键词：Fusariosis ; Onychomycosis ; Invasive fungal disease ; Risk factor ; Hematologic disease
- 刊名：Journal of Infection
- 出版年：January, 2014
- 年：2014
- 卷：68
- 期：1
- 页码：85-89
- 全文大小：256 K
Summary
Objectives
To evaluate the frequency of skin colonization by Fusarium spp. in high-risk hematologic patients and its impact on the subsequent development of invasive fusariosis.Methods
We screened all high-risk hematologic patients from August 2008 to December 2009 with cultures of 6 pre-defined areas in the feet and hands on admission and at discharge. In addition, cultures of any skin lesion present on admission were performed.
Results
Among 61 patients screened, alterations in the skin and/or nails were present in 32 patients (52%) on admission, mostly represented by abnormal appearing nails and intertrigo. Four patients (7.2%) presented positive baseline cultures for Fusarium spp., all in existing lesions of onychomycosis, intertrigo or both. Invasive fusariosis was diagnosed in six patients. The presence of a skin lesion at baseline that grew Fusarium spp. was associated with the subsequent development of invasive fusariosis (p聽=聽0.04).
Conclusions
Our data suggest that: 1) baseline cultures in patients without alterations in the skin and/or nails seems not justifiable; 2) cultures of pre-existing lesions may help to identify a group of patients at higher risk to develop invasive fusariosis. The use of anti-mould prophylaxis in this setting should be explored in future studies.