Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice
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- 作者：Zsolt Bagosi ; bagosi.zsolt@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author ; Mikló ; s Palotai ; Balá ; zs Simon ; Pé ; ter Bokor ; Andrá ; s Buzá ; s ; Beá ; ta Balangó ; Dá ; vid Pinté ; r ; Mikló ; s Já ; szberé ; nyi ; Krisztina Csabafi ; Gyula Szabó
- 关键词：Nicotine ; Urocortin ; Anxiety ; Depression ; Corticosterone ; Mice
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1652
- 期：Complete
- 页码：21-29
- 全文大小：1094 K
文摘
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Mice exposed to chronic nicotine treatment expressed signs of anxiolysis/depression.
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These mice presented a slighty increased plasma corticosterone concentration.
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Mice exposed to acute nicotine withdrawal expressed signs of anxiety/depression.
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These mice presented a remarkably increased plasma corticosterone concentration.
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Treatment with urocortin 2/3 ameliorated the anxiety and depression-like state developed.