Alzheimer's disease: brain expression of a metabolic disorder?

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• 作者：Sara Merlo ; Simona Spampinato ; Pier Luigi Canonico ; Agata Copani ; Maria Angela Sortino
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：21
• 期：9
• 页码：537-544
• 全文大小：258 K

文摘

Alzheimer's disease (AD) is the most common form of dementia and is of rapidly increasing health, social and economic impact. Recent evidence suggests a strict link between metabolic disorders and AD. In the last decade much attention has focused specifically on the connection between dysfunction of lipid metabolism and AD. Here we discuss aspects of lipid regulation, including changes in cholesterol levels, function of apolipoproteins and leptin, and how these relate to AD pathogenesis. Despite the vast literature available, many aspects still need clarification. Nevertheless, the route is already delineated to directly connect aspects of lipid regulation to AD. This could represent a starting point to identify novel potential targets for a preventive and/or treatment strategy of the disease.