Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation

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• 作者：Tiziana Bruno ; Agata Desantis ; Gianluca Bossi ; Silvia Di Agostino ; Cristina Sorino ; Francesca De Nicola ; Simona Iezzi ; Annapaola Franchitto ; Barbara Benassi ; Sergio Galanti ; Francesca La Rosa ; Aristid
• 刊名：Cancer Cell
• 出版年：2010
• 出版时间：9 August 2010
• 年：2010
• 卷：18
• 期：2
• 页码：122-134
• 全文大小：1708 K

文摘

Summary

Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53.