Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
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- 作者：Henrik N. Klø ; verpris1 ; 2 ; henrik.kloverpris@k-rith.org" class="auth_mail" title="E-mail the corresponding author ; Samuel W. Kazer3 ; 4 ; 5 ; 6 ; Jenny Mjö ; sberg7 ; Jenniffer M. Mabuka1 ; Amanda Wellmann1 ; Zaza Ndhlovu8 ; Marisa C. Yadon1 ; Shepherd Nhamoyebonde1 ; Maximilian Muenchhoff8 ; 9 ; Yannick Simoni10 ; Frank Andersson11 ; Warren Kuhn12 ; Nigel Garrett13 ; 14 ; Wendy A. Burgers15 ; Philomena Kamya3 ; 8 ; Karyn Pretorius8 ; Krista Dong3 ; Amber Moodley3 ; Evan W. Newell10 ; Victoria Kasprowicz1 ; Salim S. Abdool Karim14 ; 16 ; Philip Goulder8 ; 9 ; Alex K. Shalek3 ; 4 ; 5 ; 6 ; 17 ; Bruce D. Walker3 ; 8 ; 18 ; Thumbi Ndung&rsquo ; u1 ; 3 ; 8 ; 19 ; Alasdair Leslie1 ; 3
- 关键词：innate lymphoid cells ; HIV-1 infection
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：391-405
- 全文大小：4737 K
文摘
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ILCs are depleted from the blood during early acute HIV-1 infection
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Antiretroviral therapy initiated in acute, but not chronic, infection preserves ILCs
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RNA sequencing of ILCs during acute infection implicates apoptosis in their depletion
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Remaining ILCs in chronic disease are activated but do not migrate to tissue sites