Resveratrol inhibits lipogenesis of 3T3-L1 and SGBS cells by inhibition of insulin signaling and mitochondrial mass increase
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- 作者：Shuijie Lia ; b ; Cé ; lia Bouzara ; b ; Cé ; cile Cottet-Roussellea ; b ; Ivana Zagottac ; Fré ; dé ; ric Lamarchea ; b ; Martin Wabitschc ; Malgorzata Tokarska-Schlattnera ; b ; Pamela Fischer-Posovszkyc ; Uwe Schlattnera ; b ; Denis Rousseaua ; b ; Denis.Rousseau@univ-grenoble-alpes.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：SGBS ; Simpson&ndash ; Golabi&ndash ; Behmel syndrome ; ATAD3 ; ATPase family AAA domain-containing protein 3 ; ACC ; acetyl-CoA carboxylase ; AMPK ; AMP-activated protein kinase
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1857
- 期：6
- 页码：643-652
- 全文大小：2246 K
文摘
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We show that resveratrol inhibits lipogenesis of human and rodent pre-adipocytes undergoing in vitro differentiation.
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We described that this effect is early and limiting the initial mitochondrial mass increase and remodeling.
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We point out that resveratrol action involved the Akt inhibition and maintained AMPK activity.