Endometrial LGR7 expression during menstrual cycle
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- 作者：Maria Rosaria Campitiello ; Pasquale De Franciscis ; Daniela Mele ; Gaia Izzo ; Antonio Sinisi ; Giovanni Delrio ; Nicola Colacurci
- 关键词：Relaxin receptor ; LGR7 ; human endometrium ; implantation ; endometrial receptivity
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：30 June 2011
- 年：2011
- 卷：95
- 期：8
- 页码：2511-2514
- 全文大小：170 K
文摘
In a prospective observational study, 50 healthy patients aged 18–39 years, with regular ovulatory cycle and normal hormone levels, underwent endometrial biopsy in the proliferative and secretory phase of the menstrual cycle for semiquantitative reverse-transcription polymerase chain reaction analysis of mRNA for LGR7, the classic relaxin receptor. LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation.