- 作者：Catherine de Blacam ; Jennifer Gray ; Terence Boyle ; M. John Kennedy ; Donal Hollywood ; Javaid Butt ; Mairead Griffin ; Siobhan Nicholson ; Barbara Dunne ; Graham Wilson ; Ronan McDermott ; Pauline Murphy ; Ireneus Short ; Suzanne Rowley ; Elizabeth Connolly ; John V. Reynolds
- 关键词：Breast cancer ; Audit ; Outcome ; Multimodal therapy
- 刊名：The Breast
- 出版年：2008
- 出版时间：August 2008
- 年：2008
- 卷：17
- 期：4
- 页码：412-417
- 全文大小：214 K
BackgroundA national initiative in Ireland in 2000 defined 13 designated Units to provide care for symptomatic breast cancer, and resources, including an ability to develop audit programmes, were provided. In the absence of a national audit of breast cancer outcomes, the aim of this study is to provide a detailed report of one Unit's subsequent experience, in particular comparing process and outcome data with international norms and benchmarks, and to infer on the likely impact of the national initiative.Methods
A 5-year prospective audit of patients presenting to the Symptomatic Breast Clinic from 2001 to 2005 was conducted. All cancer diagnoses were discussed at the Breast Multidisciplinary Conference, and all clincopathological treatment details and follow-up information were entered by a full-time data manager. Overall survival was calculated using the Kaplan–Meier method.
Results
Eight hundred and thirty-nine patients were diagnosed through the clinic, 18 (2 % ) Stage 0, 169 (20 % ) Stage I, 380 (45 % ) Stage II, 142 (17 % ) Stage III, and 123 (15 % ) Stage IV. At a median follow-up of 35 months the overall 5-year survival was 71 % , with 100 % , 91 % , 83 % , 72 % , and 11 % survival for Stages 0–IV, respectively, and disease-specific survival of 82 % .
Conclusions
The process and outcome data are consistent with international benchmarks. These data from one designated centre support the national initiatives in Ireland to restructure breast services.