Reduced hedonic capacity in euthymic bipolar subjects: A trait-like feature?

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• 作者：Marco Di Nicola^a ; ^d ; ^{mdnicola@libero.it} ; Luisa De Risio^a ; Claudia Battaglia^a ; Giovanni Camardese^a ; Daniela Tedeschi^a ; Marianna Mazza^a ; Giovanni Martinotti^c ; Gino Pozzi^a ; Cinzia Niolu^b ; Massimo Di Giannantonio^c ; Alberto Siracusano^b ; Luigi Janiri^a ; ^d
• 关键词：Anhedonia ; Affective disorders ; Dopaminergic system ; Reward circuit
• 刊名：Journal of Affective Disorders
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：147
• 期：1-3
• 页码：446-450
• 全文大小：176 K

文摘

Background

The aim of our study was to assess hedonic capacity in euthymic bipolar subjects, identifying possible differences compared to remitted unipolar depressed patients and healthy controls.

Methods

107 subjects with bipolar disorders, 86 with major depressive disorder and 106 healthy controls, homogeneous with respect to demographic characteristics, were enrolled. The following scales were administered: the Snaith-Hamilton pleasure scale (SHAPS), the subscale for ¡®anhedonia/asociality¡¯ of the scale for the assessment of negative symptoms (SANS) and the visual analogue scale (VAS) for hedonic capacity.

Results

Scores on SHAPS total, interests and social interactions, SANS ¡®anhedonia/asociality¡¯ and VAS were all significantly higher in affective disorder patients compared to healthy controls. No difference was found between clinical groups. 20.5 % (n=22) of bipolar disorder subjects and 24.5 % (n=21) of major depressed subjects showed a significant reduction in hedonic capacity (SHAPS total score ¡Ý3), compared to 7.5 % (n=8) of healthy controls (¦Ö²=12.03; p=.002).

Limitations

Limitations include heterogeneity with respect to pharmacological status and longitudinal course (i.e., ¡®single¡¯ vs. ¡®recurrent¡¯ affective episodes).

Conclusions

The major finding of our study is that euthymic bipolar patients and remitted major depressed patients display residual anhedonic symptoms. This suggests that, in affective disorder patients, altered hedonic capacity could represent an enduring trait and that, possibly, dysfunctions in the neurobiological mechanisms underlying hedonic response and reward processing persist, irrespective of mood state.