PEG-liposomes (Stealth liposomes) incorporating G2-Chol40% showed low particle size with high siRNA loading efficiency and high stability against extracellular matrix.
Incorporation of G2-Chol40% micelles into PEG-liposome attenuated their cytotoxicity to a great extent.
Anti-VEGF siRNA loaded PEG-liposomes incorporating G2-Chol40% was able to transfect cells efficiently and showed endosomolytic activity.
A superior sequence-specific inhibition of VEGF secretion and SKBR-3 cell growth was achieved by anti-VEGF siRNA loaded PEG-liposomes incorporating G2-Chol40% in comparison to dendriplexes.