Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats
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- 作者：Z. Ponsa ; M. Margalefa ; F.I. Bravoa ; A. Arola-Arnala ; anna.arola@urv.cat" class="auth_mail" title="E-mail the corresponding author ; B. Muguerzaa ; b
- 关键词：(+)-Catechin (PubChem CID ; 9064) ; (&minus ; )-Epicatechin (PubChem CID ; 72276) ; (&minus ; )-Epigallocatechin gallate (PubChem CID ; 65064) ; Gallic acid (PubChem CID ; 370) ; Procyanidin B2 (PubChem CID ; 122738) ; Protocatechuic acid (PubChem CID ; 72) ; Sirtinol (PubChem CID ; 5717148)
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：24
- 期：Complete
- 页码：164-172
- 全文大小：1242 K
文摘
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Sirtuin-1 mediates the antihypertensive effect of grape seed flavanols.
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Grape seed flavanols upregulate aortic eNOS and Sirt-1 gene expression.
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Grape seed flavanols downregulate aortic NOX4 and ET-1 gene expression and plasma ET-1 levels.
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Grape seed flavanols improve endothelial pattern.