Immunomodulatory properties of gamithromycin and ketoprofen in lipopolysaccharide-challenged calves with emphasis on the acute-phase response
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- 作者：Elke Plessersa ; Heidi Wynsa ; Anneleen Watteyna ; Bart Pardonb ; Siegrid De Baerea ; Stanislas U. Sysb ; Patrick De Backera ; Siska Croubelsa ; Siska.Croubels@UGent.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：+CONTR ; positive control ; AUC ; area under the curve ; BRD ; bovine respiratory disease ; BW ; body weight ; COX ; cyclooxygenase ; DEX ; dexamethasone ; GAM ; gamithromycin ; HR ; heart rate ; KETO ; ketoprofen ; LOD ; limit of detection ; LOQ ; limit of quantification ; MRM ; multiple reaction monitoring ; MS/MS ; tandem mass spectrometry ; m/z ; mass-to-charge ratio ; N2 ; nitrogen ; NF-κB ; nuclear factor κB ; NSAID ; non-steroidal anti-inflammatory drug ; p.c. ; post LPS challenge ; PG ; prostaglandin ; PGE2-met ; 13 ; 14-dihydr
- 刊名：Veterinary Immunology and Immunopathology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：171
- 期：Complete
- 页码：28-37
- 全文大小：993 K
文摘
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We studied the immunomodulatory properties of ketoprofen, gamithromycin and their combination.
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We used a lipopolysaccharide-inflammation model in 4-week-old calves.
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We examined clinical signs, TNF-α, IL-6, serum amyloid A and prostaglandin E2.
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Ketoprofen significantly reduced clinical signs and prostaglandin E2 synthesis.
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Gamithromycin had no influence in this model.