Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells
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- 作者：Nathan Broekaerta ; Mathias Devreesea ; Mathias.devreese@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Kristel Demeyerea ; Franz Berthillerb ; Herbert Michlmayrc ; Elisabeth Vargab ; Gerhard Adamc ; Evelyne Meyera ; Siska Croubelsa ; siska.croubels@ugent.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-acetyl-deoxynivalenol (3ADON) ; 15-acetyl-deoxynivalenol (15ADON) ; Deoxynivalenol-3-β-D-glucoside (DON3G) ; IPEC-J2 ; Flow cytometry ; Apoptosis ; Necrosis
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：103-109
- 全文大小：1883 K
文摘
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Flow cytometry with Annexin-V-FITC and PI allowed discrimination of viable, apoptotic and necrotic IPEC-J2 cells.
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Cytotoxicity for proliferative cells can be ranked as follows: DON3G ≪ 3ADON < DON ≈ 15ADON.
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Differentiated IPEC-J2 cells are less susceptible to the evaluated mycotoxins compared to their proliferative counterparts.