Factors associated with persistence of arthralgia among chikungunya virus-infected travellers: Report of 42 French cases

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• 作者：Sophie Larrieu ; Nicolas Pouderoux ; Thierry Pistone ; Laurent Filleul ; Marie-Catherine Receveur ; Daouda Sissoko ; Khaled Ezzedine ; Denis Malvy
• 刊名：Journal of Clinical Virology
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：47
• 期：1
• 页码：85-88
• 全文大小：224 K

文摘

Background

In 2005–2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before.

Objectives

To describe the frequency and related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France.

Study design

All patients recruited through the travel clinic and tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, and confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression.

Results

Among the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, and most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Island, and when initial phase lasted 30 days or more and was characterised by a severe pain.

Conclusions

Consistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition and management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome.