Concise synthesis of valuable chiral N-Boc-β-benzyl-β-amino acid via construction of chiral N-Boc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation

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• 作者：Hong-Tao Jiang^a ; ^{jht@zjut.edu.cn} ; Hao-Ling Gao^a ; Cheng-Sheng Ge^a ; ^b ; ^{gechengsheng@qzu.zj.cn}
• 关键词：Synthetic methods ; Conjugate addition ; Organocatalysis ; Asymmetric catalysis ; Enantioselective
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：471-475
• 全文大小：520 K
• 卷排序：28

文摘

Valuable chiral N-Boc-β-benzyl-β-amino acid was concisely synthesized via construction of chiral N-Boc-3-benzyl-5-oxoisoxazolidine through cross-metathesis/conjugate addition/oxidation. All of the starting materials for the synthesis of chiral N-Boc-β-benzyl-β-amino acid are cheap, and two-step short procedure make it easy for the rapid construction of various chiral β-arylmethyl-β-amino acids and important drugs, such as sitagliptin phosphate.