Characterization of founder viruses in very early SIV rectal transmission

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• 作者：Zhe Yuan^a ; Fangrui Ma^a ; Andrew J. Demers^a ; Dong Wang^b ; Jianqing Xu^c ; Mark G. Lewis^d ; Qingsheng Li^a ; ^qli@unl.edu
• 关键词：Very early virological events ; Rectal transmission ; Genetic bottleneck ; Founder virus signature ; Tissue compartmentalization ; Defective variants
• 刊名：Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：502
• 期：Complete
• 页码：97-105
• 全文大小：1155 K
• 卷排序：502

文摘

Founder viruses are animal-specific in SIV rectal transmission in rhesus macaques Founder viruses are preferentially derived from rare variants in the inoculum. No tissue compartmentalization of founder viruses for the majority of macaques Post-transmission defective viruses were derived by frameshift mediated mutations