Synergistic antivirus effect of combined administration of Combivir with Angelica polysaccharide sulfate

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• 作者：Tiehong Yang^a ; ^d ; ¹ ; ^{thyang72@hotmail.com} ; Min Jia^a ; ¹ ; Zhenggang Yue^a ; ^d ; Ying Cheng^c ; Xinxin Zhang^b ; Junjie Huang^b ; Siyuan Zhou^c ; ^{zhousy@fmmu.edu.cn} ; Qibing Mei^a ; ^d ; ^{qbmei@hotmail.com}
• 关键词：Polysaccharide sulfate ; Combivir ; Synergistic effect
• 刊名：International Journal of Biological Macromolecules
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：53
• 期：Complete
• 页码：122-126
• 全文大小：414 K

文摘

This study is to investigate the synergistic effect of Anglica polysaccharide sulfate (APS-1) and Combivir, an anti-AIDS drug, on murine leukemia virus in vivo. As the results shown, the virus replication was significantly decreased by the combination of APS-1 and Combivir, which tended to be further decreased (58 % inhibition) when compared with that of Combivir alone (51 % inhibition). Furthermore, both the percentage of CD4⁺ cells and CD4⁺/CD8⁺ ratio in peripheral blood cells were significantly enhanced by this combined administration, while the CD4⁺ cells was only slightly increased and CD4⁺/CD8⁺ ratio was not affected by Combivir alone. Additionally, combination of APS-1 and Combivir also alleviated the toxicity of Combivir. APS-1 not only increased the survival rate of mice administered with LD₅₀ dose of Combivir, but also reduced the hematologic toxicity induced by Combivir, RBC, HGB and PLT were restored to normal level. These results suggest that APS-1 had synergistic effect with Combivir, which provided new insight into the potential clinical use of polysaccharide sulfate in anti-AIDS field.