Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length
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- 作者：Dmitry Zubakova ; Fan Liua ; b ; Iris Kokmeijera ; Ying Choia ; Joyce B.J. van Meursc ; Wilfred F.J. van IJckend ; André ; G. Uitterlindenc ; e ; Albert Hofmane ; Linda Broerc ; Cornelia M. van Duijne ; Jö ; rn Lewinf ; Manfred Kaysera ; m.kayser@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human age estimation ; Blood biomarkers ; Forensic ; DNA methylation ; Gene expression ; mRNA ; sjTREC ; Telomere length
- 刊名：Forensic Science International: Genetics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：24
- 期：Complete
- 页码：33-43
- 全文大小：1689 K
文摘
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Estimating a person’s age from blood left at a crime scene provides crucial forensic information.
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We studied the age effect of mRNA, DNA methylation, sjTREC, telomere length in blood.
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Genome-wide marker search was followed by rigorous technical and biological validations.
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Overall, DNA methylation markers outperformed in age correlation all other biomarkers tested.
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A model with 8 DNA methylation markers achieved high accuracy in estimating age from blood.