Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD

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• 作者：P. Cebollero^a ; F. Zambom-Ferraresi^b ; M. Herná ; ndez^a ; J. Hueto^a ; J. Cascante^a ; M.M. Anton^b ; ^{milagros.anton@unavarra.es}
• 关键词：Chronic obstructive pulmonary disease ; Inspiratory fraction ; Muscle mass ; Muscle strength ; Limb muscle dysfunction ; Muscle power
• 刊名：Revista Portuguesa de Pneumologia (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：23
• 期：1
• 页码：3-9
• 全文大小：816 K
• 卷排序：23

文摘

An inspiratory capacity to total lung capacity (IC/TLC) ratio of ≤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown.MethodsThirty-five men with moderate to severe COPD were divided into those with IC/TLC ≤ 25% (n = 16) and >25% (n = 19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity.ResultsTotal MMT in the IC/TLC < 25% group was significantly lower (413.91 ± 89.42 cm3) (p < 0.001) than in the IC/TLC > 25% group (575.20 ± 11.76 cm3). In the IC/TLC ≤ 25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36–56% lower (p < 0.01) than among the patients in the IC/TLC > 25% group.ConclusionIC/TLC ≤ 25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC ≤ 25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction.