Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle

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• 作者：Anita Helinska ; Maciej Krupa ; Karolina Archacka ; Areta M. Czerwinska ; Wladyslawa Streminska ; Katarzyna Janczyk-Ilach ; Maria A. Ciemerych ; Iwona Grabowska ; ^{igrabowska@biol.uw.edu.pl}
• 关键词：ES cells ; Myoblasts ; Skeletal muscle ; Differentiation ; Pax7 ; 5-azacitidine
• 刊名：European Journal of Cell Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：96
• 期：1
• 页码：47-60
• 全文大小：4703 K
• 卷排序：96

文摘

ESCs lacking Pax7 expressed higher levels of factors associated with myogenesis. In vivo Pax7-/- ESCs more efficiently colonized skeletal muscle than control ones. Differentiating Pax7-/- ESCs are more prone to initiate myogenic differentiation.