Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells
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- 作者：Nobuaki Ozekia ; ozeki@g.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Makio Mogib ; Naoko Hasea ; Taiki Hiyamaa ; Hideyuki Yamaguchia ; Rie Kawaia ; Toru Matsumotoa ; Kazuhiko Nakataa
- 关键词：Atg7 ; Wnt16 ; Matrix metalloproteinase-13 ; Skeletal muscle stem cell ; Osteoblast ; Cell differentiation
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 September 2016
- 年：2016
- 卷：347
- 期：1
- 页码：24-41
- 全文大小：4313 K
文摘
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BMP-2-induced Atg7 causes an increase in osteoblastic differentiation.
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Osteoblastic differentiation also requires Wnt16 and its receptor Lrp5/Fzd2.
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BMP-2 causes accumulation of autophagosomes in differentiated cells.
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Induced cell differentiation involves Atg7, Wnt16, and MMP-13 sequentially.