Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases
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- 作者：Jessica Lenzia ; b ; Francesca Pagania ; Riccardo De Santisa ; b ; Cristina Limatolac ; Irene Bozzonia ; b ; d ; Silvia Di Angelantonioa ; c ; Alessandro Rosab ; alessandro.rosa@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Induced Pluripotent Stem Cells ; Amyotrophic Lateral Sclerosis ; FUS/TLS ; TDP-43 ; Skeletal muscle
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：17
- 期：1
- 页码：140-147
- 全文大小：1065 K
文摘
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A novel method for inducing iPSCs differentiation into muscle is presented
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Multiple inducible lines can be easily generated by a new transposable vector
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Both control and iPSCs carrying ALS mutations can generate functional muscle fibers
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This system will be instrumental to study non-cell autonomous contributions to ALS