The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage

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• 作者：Stig Hill Christiansen^a ; ^{stig.hill@biomed.au.dk} ; Xianwei Zhang^a ; ^{xianwei.zhang@biomed.au.dk} ; Kristian Juul-Madsen^a ; ^{juul-madsen@biomed.au.dk} ; Michael Lykke Hvam^b ; ^{mhvam@inano.au.dk} ; Brian Stougaard Vad^b ; ^{bsv@chem.au.dk} ; Manja Annette Behrens^b ; ^{mab@inano.au.dk} ; Ida Lysgaard Thygesen^b ; ^c ; ^{idathyge@gmail.com} ; Babak Jalilian^a ; ^{jalilian.b@gmail.com} ; Jan Skov Pedersen^b ; ^{jsp@chem.au.dk} ; Kenneth A. Howard^b ; ^d ; ^{kenh@inano.au.dk} ; Daniel E. Otzen^b ; ^{dao@inano.au.dk} ; Thomas Vorup-Jensen^a ; ^b ; ^d ; ^e ; ^f ; ^{vorup-jensen@biomed.au.dk}
• 关键词：Cationic co-polymers ; Glatiramoids ; Immunotherapy ; Cathelicidins
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：425-437
• 全文大小：3719 K
• 卷排序：1859

文摘

The random-copolymer glatiramer acetate (GA) treats multiple sclerosis. GA and the anti-microbial peptide LL-37 kill human T lymphocytes. The mechanism for killing is rapid and depends on sialic acid in the cell membrane. Killing is associated with deformation of the cell membrane. GA shares oligomeric and chemical properties with anti-microbial peptides.