A transcriptional profile of the decidua in preeclampsia

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• 作者：Mari L&#xf8 ; set ; Siv B. Mundal ; Matthew P. Johnson ; Mona H. Fenstad ; Katherine A. Freed ; Ingrid A. Lian ; Irina P. Eide ; Line Bj&#xf8 ; rge ; John Blangero ; Eric K. Moses ; Rigmor Austgulen
• 关键词：decidua ; genomewide gene expression ; microarray ; preeclampsia
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：204
• 期：1
• 页码：84.e1-84.e27
• 全文大小：1143 K

文摘

Objective

We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis.

Study Design

Genomewide transcriptional profiling was performed on decidua basalis tissue from preeclamptic (n = 37) and normal (n = 58) pregnancies. Differentially expressed genes were identified and merged into canonical pathways and networks.

Results

Of the 26,504 expressed transcripts detected, 455 were differentially expressed (P < .05; false discovery rate, P < .1). Both novel (ARL5B, SLITRK4) and previously reported preeclampsia-associated (PLA2G7, HMOX1) genes were identified. Pathway analysis revealed that tryptophan metabolism, endoplasmic reticulum stress, linoleic acid metabolism, notch signaling, fatty acid metabolism, arachidonic acid metabolism, and NRF2-mediated oxidative stress response were overrepresented canonical pathways.

Conclusion

In the present study single genes, canonical pathways, and gene-gene networks that are likely to play an important role in the pathogenesis of preeclampsia have been identified. Future functional studies are needed to accomplish a greater understanding of the mechanisms involved.