Retrospective study.
Academic research environment.
All 203 patients with testicular cancer who required chemotherapy in the period 1995–2003 were included.
In 107 patients semen samples were stored by cryopreservation; 62 patients could be analyzed because both semen was stored and hormones were determined before starting chemotherapy (median age 25 years, range 17–49 years).
Total motile sperm count, T, E2, LH, FSH, and PRL.
Total motile sperm count was decreased in patients with increased β-hCG (median 11.9 × 106) compared with patients with normal β-hCG (median 21.5 × 106). Testosterone, E2, and PRL were significantly higher in patients with increased β-hCG levels, whereas LH and FSH were lower. Semen quality was significantly and negatively correlated with β-hCG, E2, and PRL.
Patients with increased β-hCG had an inferior spermatogenesis compared with patients with normal β-hCG. Increased β-hCG appears to be associated with impaired spermatogenesis and increased levels of E2 and PRL.