Streptozotocin inhibits synaptic transmission and edaravone attenuates streptozotocin-induced electrophysiological changes in CA1 pyramidal neurons of rat hippocampal slices

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• 关键词：Streptozotocin ; Edaravone ; Pyramidal neuron ; Slice patch clamp ; EPSC ; IPSC
• 刊名：NeuroToxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：75-86
• 全文大小：2378 K
• 卷排序：57

文摘

The acute and chronic effects of streptozotocin on excitatory and inhibitotary synaptic transmission in CA1 pyramidal neurons of rat hippocampal slices were tested. Streptozotocin decreased the frequencies and amplitudes in postsynaptic currents. Edaravone attenuated these streptozotocin-induced changes in synaptic transmission.