- 作者：Ingo Slottosch ; MD ; ingo.slottosch@uk-koeln.de ; Oliver Liakopoulos ; MD ; Elmar Kuhn ; MD ; Antje-Christin Deppe ; MD ; Maximilian Scherner ; MD ; Navid Madershahian ; MD ; Yeong-Hoon Choi ; MD ; Thorsten Wahlers ; MD
- 关键词：Cardiac surgery ; Extracorporeal membrane oxygenation ; ECMO ; Postcardiotomy cardiogenic shock
- 刊名：Journal of Surgical Research
- 出版年：2013
- 出版时间：15 May, 2013
- 年：2013
- 卷：181
- 期：2
- 页码：e47-e55
- 全文大小：409 K
Background
We assessed the short-term outcomes and predictors of 30-d mortality in patients requiring temporary, peripheral extracorporeal membrane oxygenation (ECMO) for postcardiotomy cardiac failure.Methods
The data were retrospectively obtained using our institutional patient database. All patients who had received peripheral ECMO support after surgery for acquired heart disease from 2006 to 2010 were included in the present study. The demographic and perioperative variables of the 30-d survivors and nonsurvivors were compared using the chi-square and t-test, and multivariate logistic regression analysis was performed to identify the predictors of 30-d all-cause mortality.
Results
A total of 77 patients with a mean age of 60 ¡À 13 years were included in the present analysis. Successful weaning from peripheral ECMO was achieved in 62 % after 79 ¡À 57 h of ECMO support. The overall 30-d mortality rate was 70 % , and mortality was reduced to 52 % in the patients in whom ECMO support could be weaned successfully. Age (per year) at ECMO implantation was the only independent preoperative predictor of 30-d mortality (odds ratio 1.09, 95 % confidence interval 1.03-1.15; P = 0.003). In addition, greater lactate levels after 24 h of ECMO therapy, a longer duration of ECMO support, and the presence of any ECMO-related or gastrointestinal complications were independent predictive factors for 30-d mortality (P < 0.05).
Conclusions
ECMO therapy provides a valuable therapeutic strategy for postcardiotomy myocardial failure but is still limited by high complication rates with fewer than 30 % of patients discharged from the hospital. Patient age appears to be an essential preoperative predictor for mortality, and the blood lactate level is a relevant marker for the assessment of efficient ECMO support.