Microwave-assisted methylation of phenols with tetramethylammonium chloride in the presence of K₂CO₃ or Cs₂CO₃

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• 作者：Nenad Maraš ; Slovenko Polanc ; Marijan Koč ; evar
• 刊名：Tetrahedron
• 出版年：2008
• 出版时间：15 December 2008
• 年：2008
• 卷：64
• 期：51
• 页码：11618-11624
• 全文大小：798 K

文摘

We have evaluated the potential of using tetramethylammonium chloride (Me₄NCl) as an alternative methylating agent for phenols under microwave-assisted conditions. Its chemical behavior was tested in a reaction with 2-naphthol in the presence of various bases and solvents. The method was then applied in 1,2-dimethoxyethane or toluene under heterogeneous conditions for the O-methylation of a series of phenolic compounds. We found that many simple phenols can be methylated in the presence of K₂CO₃, whereas some other less-reactive phenols require the presence of the more reactive Cs₂CO₃.