A rapid and simple amine-catalyzed microwave-assisted isomerization of maleamides into fumaramides

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• 作者：Vita Majce^a ; Marijan Koč ; evar^a ; Slovenko Polanc ; ^a ; ^{slovenko.polanc@fkkt.uni-lj.si"" rel=""nofollow}
• 关键词：Amine catalysis ; Microwave irradiation ; Isomerization ; Fumaramides
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：29 June 2011
• 年：2011
• 卷：52
• 期：26
• 页码：3287-3290
• 全文大小：322 K

文摘

An improved, efficient, and simple method for the synthesis of nonsymmetrical diamides of fumaric acid is reported. Starting from commercially available substrates, maleic diamides are formed in two steps, and then isomerized in a focused microwave reactor in acetonitrile as the solvent in the presence of a catalytic amount of piperidine, giving the corresponding fumaramides in high yields and purity.