Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
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文摘

Omic analysis in human liver reveals aberrant pathways in obesity and diabetes.

Genes regulating glycolysis and de novo lipogenesis were hypomethylated in obesity.

DNA methylation of ATF binding elements alters hepatic gene expression.

Obesity shifts the epigenome to increase lipid production and insulin resistance.

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