Contribution of Bistability and Noise to Cell Fate Transitions Determined by Feedback Opening
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- 作者：Chieh Hsu1 ; 2 ; &dagger ; ; Vincent Jaquet1 ; &dagger ; ; Farzaneh Maleki1 ; Attila Becskei1 ; attila.becskei@unibas.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：TF ; transcription factor ; dox ; doxycycline ; ORF ; open reading frame ; smFISH ; single molecule fluorescence in situ hybridization ; S ; logarithmic sensitivity ; fOLM ; open-loop function ; fEQ ; equivalence function ; Smax(ω) ; maximal sensitivity of the fOLM ; rtTA ; reverse tetracycline transactivator ; GEV ; Gal4-estrogen receptor-Vp16 ; GFP ; green fluorescent protein ; I.C. ; initial condition
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：9 October 2016
- 年：2016
- 卷：428
- 期：20
- 页码：4115-4128
- 全文大小：2375 K
文摘
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The rates of transition between two cell fates or states are difficult to predict because of missing parameters and the strong effect of noise.
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We predict the rates with a method termed feedback opening; the predictions are in good agreement with the observed rates.
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When feedback loops are opened experimentally, the resulting open-loop function determines whether the parent feedback loop has one or two stable states.
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Hysteresis may be absent in bistable feedback loops.