Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress

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• 作者：Debarati Mukherjee^a ; ¹ ; Chingakham Brajakishor Singh^b ; ¹ ; Somaditya Dey^a ; ² ; Supratim Mandal^a ; ³ ; Joydip Ghosh^a ; Suvadip Mallick^a ; Aabid Hussain^a ; Ningombam Swapana^c ; Samir Anis Ross^d ; Chiranjib Pal^a ; ^{cpcu.immunology@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Leishmania donovani ; Zingiber zerumbet ; Zerumbone ; Anti-leishmanial ; ROS
• 刊名：The Brazilian Journal of Infectious Diseases
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：20
• 期：1
• 页码：48-55
• 全文大小：1587 K

文摘

In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmania infection. Various ginger spices of the Zingiberaceae family are widely used as spices, flavouring agents, and medicines in Southeast Asia because of their unique flavour as well as due to their medicinal properties. Zerumbone, a natural component of Zingiber zerumbet (L.) Smith, has been studied for its pharmacological potential as antiulcer, antioxidant, anticancer, and antimicrobial. In this study, we have shown that zerumbone could induce ROS mediated apoptosis in Leishmania donovani promastigotes and also found effective in reducing intracellular amastigotes in infected-macrophages. We emphasized the potential of zerumbone to be employed in the development of new therapeutic drugs against L. donovani infection and provided the basis for future research on the application of transitional medicinal plants.