The regulation of spermatogenesis by androgens
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- 作者：Lee B. Smitha ; 1 ; Lee.Smith@ed.ac.uk" class="auth_mail ; William H. Walkerb ; walkerw@pitt.edu" class="auth_mail
- 关键词：PTM ; peritubular myoid cell ; SSC ; spermatogonia stem cell ; DHT ; dihydrotestosterone ; BTB ; blood testis barrier ; AR ; androgen receptor ; SHBG ; sex hormone binding globulin ; ABP ; androgen binding protein ; FAK ; focal adhesion kinase ; ES ; ectoplasmic specialization ; ARE ; androgen response element ; EGFR ; epidermal growth factor receptor ; GDNF ; glial derived neurotrophic factor ; jsd ; juvenile spermatogonial depletion mutant ; TP ; testosterone propionate ; tfm ; testicular feminization ; GnRH ; gonadotropin
- 刊名：Seminars in Cell and Developmental Biology
- 出版年：June 2014
- 年：2014
- 卷：30
- 期：Complete
- 页码：2-13
- 全文大小：1755 K
文摘
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Testosterone maintains BTB, meiosis, Sertoli–spermatid adhesion and spermiation.
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Testosterone acts via classical and non-classical pathways.
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Testosterone regulates PTM, Leydig, and Sertoli cells via the androgen receptor.
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The combined regulation of many genes by testosterone supports spermatogenesis.