Potential role of autophagy in smokeless tobacco extract-induced cytotoxicity and in morin-induced protection in oral epithelial cells
详细信息 查看全文
- 作者：Arnab Ganguli ; Amlan Das ; Debasish Nag ; Surela Bhattacharya ; Gopal Chakrabarti ; gcbcg@caluniv.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Smokeless tobacco ; Reactive oxygen species ; Autophagy ; Morin
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：160-170
- 全文大小：2084 K
文摘
- •
STE induced ROS dependent autophagy in oral SCC25 cell line.
- •
Autophagy and apoptosis both act as cell death mechanism in STE treated SCC25 cell line.
- •
Antioxidant morin reduced ROS level, and inhibited apoptosis and autophagy, hence protects STE induced oral cytotoxicity.